The most exciting information though has to do with progesterone's ability to PREVENT and REVERSE many cancers. The newer studies show that estrogen, specifically estradiol, does not increase the risk for breast cancer but it actually CAUSES breast cancer AND prostate cancer. There is not any debate left about this issue. All major researchers have found this The information on the prostate is new.
Let me attempt to explain the relationship for prostate cancer in more detail. Men also make estrogen and estradiol, but in much lower amounts than women. The male hormone, testosterone, is antagonist to estradiol. Testosterone prevents estradiol from causing prostate cancer by destroying the prostate cancer cells it stimulates.
Testosterone does NOT cause prostate cancer. If this were true 19 and 20 year old males would be developing prostate cancer as these are the individuals with the highest levels. This is obviously not the case. Males also produce progesterone, although about half as much as females do. The progesterone prevents the body from converting testosterone to di-hydro testosterone.
It does this by inhibiting the enzyme 5-alpha reductase. Progesterone inhibits 5 alpha reductase far more effectively than Proscar and Saw Palmetto which are the more standard agents employed in traditonal and natural medicine.
As a male ages, his progesterone level decreases just like it does in women. In women this decease occurs about the age of 35 and men about ten years later. When progesterone levels decrease, the male's 5 alpha reductase converts the testosterone to di-hydro testosterone which is useless at removing the prostate cancer cells that estradiol stimulates. Estradiol also stimulates the enlargement of the prostate. This allows the prostate gland to swell and enlarge and in many cases transform into prostate cancer.
The prostate is embryologically similar to the female uterus. Prostate cancer is the NUMBER ONE cancer in men. Prostate enlargement is a major cause of problems in elderly men. It appears we now have a simple, safe inexpensive solution to prevent and treat this problem.
Dr. Lee's has a large number of anecdotal stories of complete reversals of metastatic prostatic cancers. The clinical research has just begun. Dr. Lee states that there are several studies that will be published in the peer reviewed literature very shortly confirming this observation in animal studies.
There is no need to wait for these studies as there is strong biochemical evidence to support this recommendation. The January 28 JAMA had an article To die or not to die? most cells in the body die through a more subtle, noninflammatory, energy-dependent form of cell death called apoptosis.
Recent research into the molecular mechanisms of apoptosis has revealed that apoptosis is a genetically programmed process that can become deranged when the components of the cellular apoptotic machinery are mutated or present in inappropriate quantities. Dysregulation of apoptosis is associated with the cause of a wide array of diseases: cancer, neurodegeneration, autoimmunity, heart disease, and other disorders.
All cells, with the exception of brain and muscle cells, multiply continuously. The genes which regulates this cell growth are p53 and bcl2 . If the gene bcl2 dominates it will push cells to cancer. If gene p53 dominates the opposite will occur and the cell growth is controlled and the cancer do not occur.
The article clearly shows that traditional chemotherapy using poisons to stop cell hyperplasia do not work as they kill normal cells easier than cancer cells. The new idea promoted by the review is to find agents that activate p53 and deactivate bc12 is the hope for curing cancer.
Well folks, guess what the research shows??? Estradiol turns on the cancer gene bc12 and progesterone turns on the anti-cancer gene p53!!! Breast cancer cells do not multiply when women are on progesterone. These hormones also worked for cancer of the ovary and uterus and small cell lung cancer which is normally a very difficult cancer to treat with a horribly dismal diagnosis.
Men do NOT need time off like women and can take the progesterone without taking any days off.
This is MAJOR news and will provide a radical shift in my recommendations for hormonal replacement. I know believe that nearly all men should seriously consider natural progesterone replacement sometime in their 40s, or even earlier if they have a family history of prostate cancer. There is also a reasonable likelihood that this will decrease male balding. (Dr. Mercola)